Process for the preparation of triorganoperoxyboranes

ABSTRACT

Tri(organoperoxy)boranes are prepared by the reaction of organic hydroperoxides with alkyl orthoborates at not above 90* C., in a molar ratio of at least 5:1, or 0.4:1 to 2:1 when an inert solvent is present. The products may be used to oxidize aromatic compounds to phenols.

United States Patent [72] Inventors Noel Crenne;

Jean-Claude Brunie, both of Lyon, France [2l Appl. No. 828,088 I [22] Filed May 19, 1969 [45] Patented Nov. 23, 1971 [73] Assignee Rhone-Poulenc S.A.

Paris, France [32] Priorities Apr. 21, 1965 [33] France [3 l 14026;

Sept. 29, 1965, France, No. 33152; Nov. 26, 1965, France, No. 39965 Continuation of application Ser. No. 543,016, Apr. 18, 1966, now abandoned. This application May 19, 1969, Ser. No. 828,088

[54] PROCESS FOR THE PREPARATION OF TRIORGANOPEROXYBORANES 10 Claims, No Drawings [52] U.S.Cl 260/462R [51] int. Cl C07i 5/04 [50] Field of Search 260/462, 462 R [5 6] References Cited OTHER REFERENCES Davies; A. et al., J. Chem. Soc. 1958, Part ll, pages 2372 and 2376 Primary ExaminerLeon Zitver Assistant Examiner-Leo DeCrescente Attorney-Cushman, Darby & Cushman ABSTRACT: Tri(organoperoxy)boranes are prepared by the reaction of organic hydroperoxides with alkyl orthoborates at not above 90 C., in a molar ratio ofat least 5: l or 0.4:] to 2:] when an inert solvent is present. The products may be used to oxidize aromatic compounds to phenols.

PROCESS FOR THE PREPARATION OF TRIORGANOPEROXYBORANES This application is a continuation of application Ser. No. 543,016, now abandoned.

The present invention relates to a new process for the preparation of organic peresters of orthoboric acid, more specifically to tri(organoperoxy)boranes.

it is well known that trialkylboranes can be oxidized by oxygen and that this oxidation process only affects one or two thirds of the boron-carbon bonds of the trialkylborane, thus producing borinic or boronic peresters, i.e. mono(alkylperoxy)dialkylboranes or di(alkylperoxy)alkylboranes. Tri(butylperoxy)boranes have been prepared by reacting boron trichloride with the corresponding butyl hydroperoxide (Davies and Moodie, J. Chem. Soc., 2372 (I958) The same authors tried to react propyl orthoborate with an excess of various hydroperoxides but failed to prepare the corresponding tri( organoperoxy)boranes.

A new method has now been found for obtaining tri(organoperoxy)boranes. Accordingly, the present invention relates to a process for the preparation of tri(organoperoxy)boranes of the formula:

in which R is a primary, secondary or tertiary aliphatic or alicyclic radical of at least four carbon atoms or an araliphatic radical which comprises reacting three moles of one or more organic hydroperoxides of the formula:

in which R is as hereinbefore defined, with at least one mole of one or more alkyl orthoborates of the formula:

in which R is an alkyl radical, at a temperature not above 90 C. The alkyl orthoborate may be used in excess and/or diluted with an inert solvent; the alcohol liberated by the reaction is preferably removed at the rate at which it is formed. in this specification and accompanying claims the word solvent" is used to denote any liquid organic product other than alkyl orthoborate which is inert under the reaction conditions.

The new process, which resembles a transesterification, may be represented generally by the reaction scheme.

The hydroperoxides which may be used in the process are organic compounds of formula (1) in which R is a primary, secondary or tertiary aliphatic or alicyclic radical containing at least four carbon atoms, or an araliphatic radical. More especially, R represents an alkyl or alkenyl radical of at least four carbon atoms; an unsubstituted or lower alkyl (one to four carbon atoms) substituted cycloalkyl or cycloalkenyl radical having 5- to l2-ring carbon atoms; an aralkyl radical, especially phenylalkyl; or a saturated or aromatic bicyclic radical. Most especially, R represents a butyl, pentyl, hexyl, octyl, dodecyl, cyclohexyl, methylcyclohexyl, ethylcyclohexyl, cyclohexenyl, benzyl, phenylethyl, cumyl, p-nitrocurnyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl or pinanyl radical. These compounds are now easily accessible from the corresponding alcohols or hydrocarbons (see, for example, Organic Peroxides by A. G. DAVIES).

it is not necessary to use a 100 percent pure hydroperoxide. The reaction is possible with dilute solutions of hydroperoxide in a convenient solvent. in particular, technical grade dilute solutions of hydroperoxide, obtained by the oxidation of hydrocarbons followed by the elimination of the acid derivatives by any known means, may be used; such solutions may still contain byproducts such as esters, alcohols and ketones which do not interfere with the preparation of the organoperoxyborane. For example it is possible to use a dilute which R' is preferably an alkyl radical of one to four carbon atoms having a straight or branched chain. Methyl orthoborate, which is an 'easily obtainable commercial product, is most preferred; ethyl orthoborate may also be used with advantage.

It is to be understood that the process of the invention is not limited to reactions between a specific organic hydroperoxide and a specific alkyl orthoborate. It is thus possible to react a mixture of the above hydroperoxides with one or more of the above orthoborates. However, generally reactions between a definite compound of each category is of greater interest. 1

From the above reaction scheme it is theoretically sufficient for the molar ratio of orthoborate to hydroperoxide to be equal to l:3. In practice this ratio may vary between rather wide limits, depending on whether a solvent is or is not used to dilute the reagents. If the reaction is carried out without a solvent it is necessary to work with an excess of orthoborate. In practice it is preferable for this excess to be large generally so that the above ratio is at least equal to 5:]. Usually, a ratio greater than 25:1 is of little interest. The use of a liquid solvent allows the proportion of alkyl orthoborate used to be considerably reduced. Though the reaction can, under these conditions, be carried out with the stoichiometric amounts of hydroperoxide and orthoborate, it is advantageous to use an excess of alkyl orthoborate. Amounts of orthoborate such that the ratio orthoboratezhydroperoxide has values between 0.4: l and 2:1 are generally suitable.

Only such liquids which give no reaction, or substantially no reaction with the reactants or products over the temperature range in which the reaction is carried out should be used. For example, it is possible to use aliphatic and alicyclic saturated hydrocarbons and aromatic hydrocarbons, which may, inter alia, carry substituents such as halogen atoms, e.g. chlorine or fluorine.

Together with the tri(organoperoxy)borane the reaction produces an alcohol which is preferably removed from the reaction medium at the rate at which it is formed. This removal, which generally consists of a simple distillation under the working conditions, is the easier the greater the difference between the boiling point of the alcohol and that of the hydroperoxide used. Preferably solvents are used which allow the alcohol liberated to be eliminated from the reaction mixture otherwise the unreacted alkyl borate has to be removed from the alcohol which forms a binary mixture with it. This may be achieved, for example, if the solvent chosen has a higher boiling point than the alcohol. Especially preferred solvents are those which form with the alcohol a binary azeotrope which may be removed by simple distillation under the reaction conditions; the use of such solvents is particularly advantageous where the alkyl orthoborate used is methyl orthoborate or ethyl orthoborate because it is then possible to remove, at atmospheric pressure, a binary azeotrope of solvent and alcohol which is more volatile than the binary azeotrope of orthoborate and alcohol.

When methyl orthoborate is'used, the following may be advantageously used as the solvent: l-chloropropane, 2-

-chlorobutane, l-chloro-2-methylpropane, 2-chloro-2-methylcertain applications, may be used without further treatment.

The amount of solvent varies according to the nature and quantity of the orthoborate employed. As a general rule it is preferable for the concentration, by weight, of the hydroperoxide in the mixture (hydroperoxide +orthoborate +solvent) to be less than 25 percent. Amounts of solvent which ensure that this concentration has values of between 3 percent and 20 percent are generally suitable.

The reaction temperature used depends on the stability of 5 the hydroperoxide and the nature of the orthoborate used. It is always desirable that the temperature should be as low as possible so as to avoid decomposing any of the hydroperoxide used and of the peroxyborane formed, the stability of the latter being generally less than that of the corresponding hydroperoxide. Temperatures above 90 C. are not suitable.

The reaction may be carried out at atmospheric pressure, but when the reaction mixture has a boiling point above 90 C., at this pressure, it is necessary to use a subatrnospheric pressure so as to lower the boiling point.

A typical mode of working is as follows: After having replaced the air in the apparatus by an inert gas(nitrogen or argon) a mixture of hydroperoxide, orthoborate and, optionally, solvent is heated to a temperature not greater than 90 C. and a pressure is provided such that the alcohol can be removed at the rate at which it is formed. When methyl orthoborate or ethyl orthoborate is used, the choice of suitable binary azeotropes makes it possible to work at atmospheric pressure. Subsequently the greater part of any excess orthoborate and, where appropriate, the solvent may be recovered by heating the remaining product at progressively decreasing pressures.

The tri(organoperoxy)boranes so obtained are in the form of very viscous liquids. They have the property of combining with certain amines such as pyridine to form complexes which are generally solid and insoluble in saturated hydrocarbons such as pentane and heptane.

The products prepared by the process of the invention may be used for various purposes. They are powerful oxidizing agents and in this capacity make it possible to carry out numerous oxidation reactions in organic chemistry for which the use of an alkyl hydroperoxide alone is not satisfactory. For example, phenolic compounds may be produced from aromatic compounds having at least one nuclear hydrogen atom. The compounds may bemonocyclic or polycyclic hydrocarbons and may optionally carry nonoxidizable groups such as halogen atoms or ether groups. For this oxidation it is preferable to use tri(cyclohexylperoxy)borane as it is easily obtainable from cyclohexyl hydroperoxide.

The working conditions and the proportions used depend on the aromatic compound to be oxidized, and the peroxyborane used. In general terms, the reaction temperature depends on the decomposition temperature of the peroxyborane and on the oxidizability of the aromatic compound. It is generally sufiicient to heat the mixture for l to ID hours at a temperature of between 50 and 250 C. The reaction, which is carried out in the liquid phase, may take place in an anhydrous medium, optionally in a solvent which is inert under the reaction conditions. To avoid the use of another solvent it is also possible to react the peroxyborane with an excess amount of the aromatic compound, the excess serves as diluent. In this case the molar ratio of the aromatic compound to the peroxyborane is considerably greater than the theoretical ratio of 3:1 which is necessary for carrying out the oxidation; thus a concentration of l to percent of the peroxyborane in the aromatic compound allows the reaction to be carried out advantageously. The reaction ceases when there is no more peroxyborane present in the mixture; the unconverted aromatic compound may be recycled. Hydrolysis of the residue may then be carried out, the phenol being subsequently isolated by washing the organic phase with alkali. It is also possible to subject the residue to an alcoholysis with a volatile alcohol such as methanol. or ethanol, the volatile borate being removed at the rate at which it is formed, with the phenol then being separated from the residual product by conventional means such as distillation or solvent extraction.

The following examples illustrate the invention; examples 1 to l l illustrate the preparation of the peroxyboranes and examples 12 to l5 illustrate their use as oxidizing agents.

EXAMPLE I The apparatus used consisted of a 500 cc. flask fitted with a nitrogen inlet, a thermometer sleeve, a distillation column and an analyzer, a downward-sloping condenser and a receiver linked to a bubble counter via a drying column.

The apparatus was carefully purged with nitrogen and then 30 g. of cyclohexyl hydroperoxide (97 percent purity) and 185 g. of methyl borate were introduced into the flask. The mixture was then slowly heated to boiling, which started when the temperature of the mixture reached 7 1 C.

At this temperature the methanol distilled ofl as soon as it formed as a binary azeotrope of methanol and methyl borate (boiling point 55 C.) which contained 32 percent methanol. After 30 minutes the temperature of the vapors which distilled remained constant at 5657 C. the distillation was continued until it yielded pure methyl borate (boiling point 68 C.). The temperature of the reaction mixture was then 82 C. The mixture was allowed to cool to ambient temperature and then the distillation of the excess methyl borate was continued at 15 mm. Hg pressure and finally for a further 30 minutes at 40 C./0.5 mm. Hg. This left 31.7 g. of a colorless liquid of low mobility which had a boron content of 3.3 percent [calculated for B(OOC,H 3.09 percent]. Analysis of this liquid by infrared spectrography (i/r) and nuclear magnetic resonance (NMR) showed that the structure of the principal constituent was certainly that of tri(cyclohexylperoxy)borane. By determining the reactive oxygen present it was found that the final product contained 82.5 percent of tri(cyclohexylperoxy)borane. The loss of reactive oxygen during the operation was 11.8 percent, (taking into account the purity of the hydroperoxide starting material).

EXAMPLE 2 The process was carried out as in example I replacing the cyclohexyl hydroperoxide by 35.2 g. of pure cumyl hydroperoxide. The distillation of the methyl borate/methanol azeotrope formed in the reaction took about 1 hour, the distillation was then continued until the temperature of the reaction mixture reached 75 C. The distillation was completed in vacuo as described in the preceding example, leaving 38.2 g. of a colorless liquid of low mobility. The principal constituent of this liquid (87.8 percent according to the reactive oxygen determination) was identified by i/y and NMR spectrography as tri( l-phenyl-1-methylethylperoxy)borane. 7 percent of the reactive oxygen was lost in the course of the process. EXAMPLE 3 9.2 g. of benzyl hydroperoxide (purity 91.5 percent) and 65 g. of methyl borate were introduced into an apparatus similar to that described in example I but with a 250 cc. flask. Using the procedure'of example i 9.6 g. of a thick clear yellow liquid containing, according to the reactive oxygen determination, 70 percent of a product identified as tri(benzylperoxy )borane was obtained.

EXAMPLE 4 The process was carried out as in the preceding example using 4.6 g. of methylcyclohexyl hydroperoxide (purity percent) and 82 g. of methyl borate. 5.2 g. of a clear viscous liquid containing 80.5 percent of a product identified by infrared and NMR spectrography as being tri(methylcyclohexylperoxy)borane was obtained. The loss of reactive oxygen in the course of the process was about 5.5 percent.

EXAMPLE 5 The same apparatus as in the example 3 was used. 5.15 g. of cyclohexyl hydroperoxide (90.5 percent pure) and g. of ethyl borate were introduced into the reaction flask. A reduced pressure (l50 mm. Hg) was then gradually established in the apparatus and the mixture was heated to 73 C., at which temperature boiling started. Distillation was carried out for one hour at this pressure, then at l5 mm. Hg for 30 minutes; the removal of the excess ethyl borate was completed as in the preceding examples. 6.45 g. of a clear viscous liquid containing 70 percent (according to reactive oxygen determination) of a product identified as being tri(cyclohexylperoxy)borane were obtained.

EXAMPLE 6 The process was carried out as in example 5 using 5 g. of cyclohexyl hydroperoxide (89.6 percent pure) and 125 g. of isopropyl borate. The pressure in the apparatus was reduced to 70 mm. Hg and the mixture heated up to the point at which boiling started (about 75 C.). The distillation was carried out for one hour at this pressure followed by 30 minutes at a pressure of 2.5 mm. Hg. The process was completed as in the preceding Example to give 5.9 g. of a clear liquid containing 72.5 percent of tri(cyclohexylperoxy)borane.

EXAMPLE 7 The process was carried out as in example 6, using 5 g. of cumyl hydroperoxide (97.5 percent pure) and 125 g. of propyl orthoborate. The pressure in the apparatus was reduced to l 1 mm. Hg and the mixture heated to about 77 C., at which temperature boiling started. The distillation was carried out for one hour under these conditions after which the residual propyl orthoborate was removed at 50 C. and 0.5 mm. Hg over 45 minutes. 16.9 g. of a mixture containing 68 percent of propyl orthoborate and 29 percent of tri( l-phenyl-lmethylethylperoxy)borane were obtained. There was no loss of reactive oxygen during the process.

EXAMPLE 8 The apparatus used consisted of a one litre flask equipped as in example l. This apparatus was carefully purged with nitrogen and 52.2 g. of cyclohexyl hydroperoxide (purity 95 percent), 442 g. of anhydrous cyclohexane and 66 g. of methyl orthoborate were introduced into the flask. The mixture was then progressively heated to boiling, which started at 75 C.

The methanol was distilled as soon as it formed, as a mixture of two binary azeotropes, namely methanol and cyclohexane (boiling point 54 C.), and methanol and methyl orthoborate (boiling point 55 C.) and the distillation was continued until pure cyclohexane (boiling point 80 C.) appeared. The mixture was allowed to return to ambient temperature and the cyclohexane removed first at a pressure of mm. Hg and then at 30 C./2mm. Hg for 30 minutes. 57.5 g. of a colorless liquid of low mobility having a boron content of 3.3 percent were left. Analysis of this liquid by i/r and NMR spectrography showed that the structure of the principal constituent was definitely that of tri( cyclohexylperoxy)borane. According to a reactive oxygen determination the final product contained 83.2 percent of tri(cyclohexylperoxy)borane.

EXAMPLE 9 The process was carried out as in the preceding example, using 15.8 g. of cyclohexyl hydroperoxide (90.2 percent purity), 13.1 g. of methyl orthoborate, and 135 g. of hexane. The mixture was boiled and the methanol was removed as a binary azeotrope of hexane and methanol (boiling point 50 C.). After the excess solvent and methyl orthoborate had been removed at reduced pressure (12 mm., and then 1 mm./Hg), 16.4 g. of a clear viscous oil containing 78.6 percent of tri(cycl0hexylperoxy)borane remained.

EXAMPLE 10 15.8 g. of cyclohexyl hydroperoxide (purity 95 percent), 135 g. of anhydrous cyclohexane and 10 g. of ethyl orthoborate were introduced into a 500 cc. flask equipped as in example 1.

The mixture was slowly heated to boiling, which started at 80 C. and then the ethanol was slowly distilled as it formed as a binary azeotrope of cyclohexane and ethanol (boiling point 65 C.). The distillation was continued until pure cyclohexane was obtained. The final mixture was then treated as in example l to give 19 g. of a clear liquid containing 76.3 percent of tri(cyclohexylperoxy)borane. The loss of reactive oxygen in the course of the process was 5.5 percent (taking into account the purity of the initial hydroperoxide).

EXAMPLE 1 l The apparatus consisted of a 10 litre glass vessel equipped as in example 1.

3,270 g. of a cyclohexane solution containing, by weight, 8.87 percent of cyclohexyl hydroperoxide and 3.5 percent of byproducts consisting principally of cyclohexanol, cyclohexanone and esters were introduced into the flask. (This solution was obtained by the oxidation of cyclohexane in air until a degree of oxidation of about 4 percent was achieved, followed by concentration and by washing with an aqueous sodium bicarbonate solution.)

2,530 g. of cyclohexane and 730 g. of ethyl orthoborate were then added, and the reaction carried out as in the preceding example. The final mixture (5,890 g.) in which 288 g. (i.e. 4.89 percent by weight) of tri(cyclohexylperoxy)borane were found to be present, was then immediately distilled by progressively feeding into a zone heated to 78 C. under reduced pressure (20 mm. Hg). The vaporized fraction collected after condensation (5,330 g.) contained 30.3 g. of unreacted cyclohexyl hydroperoxide. In addition 558 g. of unvaporized products containing 251 g. of tri(cyclohexylperoxy)borane, cyclohexyl orthoborate, cyclohexanone and various esters arising from the starting solution were collected. The loss of reactive oxygen was about 5.2 percent (taking into account the unreacted cyclohexyl hydroperoxide).

EXAMPLE 12 A 500 cc. flask fitted with a central stirrer unit, a vertical condenser and a nitrogen inlet was charged with 4.5 g. of tri(cyclohexylperoxy)borane of 80 percent purity, and 193 g. of phenetole. The mixture was heated for 3 hours at C. After cooling to 70 C. 50 cc. of water were added and the mixture was maintained at this temperature for 30 minutes. The mixture was decanted and the aqueous layer extracted 3 times with 50 cc. of diethyl ether. The ether layers were combined with the decanted organic layer and the mixture extracted 5 times with 50 cc. of a 10 percent aqueous sodium hydroxide solution. This aqueous solution was acidified by adding 165 cc. of 6 N hydrochloric acid solution and the phenols extracted from it 5 times with 100 cc. of diethyl ether. After washing the ethereal solution with a 10 percent aqueous sodium bicarbonate solution evaporating the solvent and drying, 3.13 g. of a mixture of ortho and para ethoxyphenols were isolated. The yield as determined iodometrically was 75 percent based on the reactive oxygen employed.

EXAMPLE 13 3.5 g. of tri(cyclohexylperoxy)borane of 85.4 percent purity and 150 g. of anisole were reacted as in the previous example. The mixture was heated for 3% hours at -l 10 C. 2.64 g. of a mixture of ortho and para methoxyphenols were obtained. Yield: 85 percent based on the reactive oxygen employed.

EXAMPLE l4 10 g. of tri(cyclohexylperoxy)borane of 79 percent purity and 465 cc. of anhydrous toluene were charged into an apparatus similar to that used in example 12 using a 1-liter flask. The mixture was heated for 6.25 hours under reflux and then cooled and hydrolyzed as in example 12. Using the separation treatment employed in example 12 3.67 g. of a mixture of ortho and para cresols were obtained. Yield: 52 percent based on the reactive oxygen employed.

EXAMPLE 15 27.5 g. of tri(cyclohexylperoxy)borane of 55 percent purity (the predominant byproducts being cyclohexyl orthoborate and cyclohexanone) and 730 g. of anisole were charged into the apparatus used in the preceding example. The mixture was heated under a nitrogen atmosphere for 3 hours at 110 C. After cooling, 682 g. of anisole were removed under reduced pressure (30 mm. Hg), and 200 cc. of methanol were added to the residue; the mixture was heated to boiling point and methyl orthoborate was removed as it formed as a binary azeotrope with methanol (boiling point 55 C.). The excess methanol was removed, the phenolic composition was extracted with caustic soda and then separated as in example 12. This gave 9.5 g. of a mixture of ortho and para methoxyphenol. The yield was 60 percent based on the reactive oxygen employed.

What is claimed is:

1. Process for the preparation of tri(organoperoxy)boranes of the formula:

in which R is alkyl of at least four carbon atoms, unsubstituted or lower alkyl-substituted cycloalkyl of 5- to l2-ring carbon atoms, unsubstituted cycloalkenyl of 5- to l2-ring carbon atoms, phenylalkyl, p-nitrocumyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl, or pinanyl, which comprises forming a reaction mixture consisting essentially of an organic hydroperoxide of the formula:

in which R is as hereinbefore defined, and an alkyl orthoborate of the formula:

in which R is an alkyl radical, and subjecting said reaction mixture to a temperature not above 90 C. under a pressure such that the reaction mixture boils at a temperature not above 90 C., and under an inert gas atmosphere, the molar ratio of orthoborate to hydroperoxide being at least 5:1.

2. Process according to claim I in which alcohol produced by the reaction is removed as it is formed.

3. Process according to claim 1 in which R is a butyl, pentyl, hexyl, octyl, dodecyl, cyclohexyl, methylcyclohexyl, ethylcyclohexyl, cyclohexenyl, benzyl, phenylethyl, cumyl, pnitrocumyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl or pinanyl radical.

4. Process according to claim 1 in which R is an alkyl radical of one to four carbon atoms.

5. Process according to claim 1 in which the alkyl orthoborate is methyl or ethyl orthoborate.

6. Process for the preparation of tri(organoperoxy)boranes of the formula:

in which R is alkyl of at least four carbon atoms, unsubstituted or lower alkyl-substituted cycloalkyl of 5- to l2-ring carbon atoms, unsubstituted cycloalkenyl of 5- to l2-ring carbon atoms, phenylalkyl, p-nitrocumyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl, or pinanyl, which comprises forming a reaction mixture consisting essentially of an organic hydroperoxide of the formula:

in which R is as hereinbefore defined, and an alkyl orthoborate of the formula:

in which R is an alkyl radical, the reaction mixture being diluted with an inert solvent such that the organic hydroperoxide constitutes less than 25 percent of the mixture of orthoborate, hydroperoxide and solvent and the molar ratio of orthoborate to hydroperoxide being between 0.4:] and 2:1 and subjecting said reaction mixture and inert solvent to a temperature not above C., under a pressure such that the reaction mixture boils at a temperature not above 90 C., and under an inert gas atmosphere.

7. Process according to claim 6 in which alcohol produced by the reaction is removed as it is formed.

8. Process according to claim 6 in which R is a butyl, pentyl, hexyl, octyl, dodecyl, cyclohexyl, methylcyclohexyl, ethylcyclohexyl, cyclohexenyl, benzyl, phenylethyl, cumyl, pnitrocumyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl or pinanyl radical.

9. Process according to claim 6 in which R is an alkyl radical of l to 4 carbon atoms.

10. Process according to claim 6 in which the alkyl orthoborate is methyl or ethyl orthoborate. 

2. Process according to claim 1 in which alcohol produced by the reaction is removed as it is formed.
 3. Process according to claim 1 in which R is a butyl, pentyl, hexyl, octyl, dodecyl, cyclohexyl, methylcyclohexyl, ethylcyclohexyl, cyclohexenyl, benzyl, phenylethyl, cumyl, p-nitrocumyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl or pinanyl radical.
 4. Process according to claim 1 in which R'' is an alkyl radical of one to four carbon atoms.
 5. Process according to claim 1 iN which the alkyl orthoborate is methyl or ethyl orthoborate.
 6. Process for the preparation of tri(organoperoxy)boranes of the formula: B(O-O-R)3 in which R is alkyl of at least four carbon atoms, unsubstituted or lower alkyl-substituted cycloalkyl of 5- to 12-ring carbon atoms, unsubstituted cycloalkenyl of 5- to 12-ring carbon atoms, phenylalkyl, p-nitrocumyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl, or pinanyl, which comprises forming a reaction mixture consisting essentially of an organic hydroperoxide of the formula: R-O-O-H in which R is as hereinbefore defined, and an alkyl orthoborate of the formula: B(OR'')3 in which R'' is an alkyl radical, the reaction mixture being diluted with an inert solvent such that the organic hydroperoxide constitutes less than 25 percent of the mixture of orthoborate, hydroperoxide and solvent and the molar ratio of orthoborate to hydroperoxide being between 0.4:1 and 2:1 and subjecting said reaction mixture and inert solvent to a temperature not above 90* C., under a pressure such that the reaction mixture boils at a temperature not above 90* C., and under an inert gas atmosphere.
 7. Process according to claim 6 in which alcohol produced by the reaction is removed as it is formed.
 8. Process according to claim 6 in which R is a butyl, pentyl, hexyl, octyl, dodecyl, cyclohexyl, methylcyclohexyl, ethylcyclohexyl, cyclohexenyl, benzyl, phenylethyl, cumyl, p-nitrocumyl, tetrahydronaphthyl, methyltetrahydronaphthyl, decahydronaphthyl, indanyl or pinanyl radical.
 9. Process according to claim 6 in which R'' is an alkyl radical of 1 to 4 carbon atoms.
 10. Process according to claim 6 in which the alkyl orthoborate is methyl or ethyl orthoborate. 